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Ganoderma lucidum (Reishi) and its properties

Ganoderma lucidum (Reishi) and its properties

Ganoderma lucidum is the best known fungus in mycotherapy and probably also the one with the highest number of studies and is generally known by the Japanese name of "Reishi", while the Chinese name is Ling Zhi or Ling chi. This basidiomycete has an almost ovoidal shape and flat hat, its surface is wavy and irregular, yet it is smooth and very shiny. Visually, the entire surface of the Ganoderma lucidum hat is divided into multiple growth rings. The stem is lateral, of the same color as the hat. The meat is woody, very leathery, of a white-ocher color. Saprophytes of hardwoods or hardwoods, especially oak, grows from spring to autumn.

Why is it so appreciated?
It is appreciated for its therapeutic properties in eastern countries, especially in China, Malaysia, Japan, where it is intensively cultivated, dried and processed into medicinal preparations (powder, decoctions, ointments, tablets, etc.). The Latin word lucidus means "shiny" or "bright" and refers to the painted appearance of the mushroom surface.
Lingzhi has been recognized as a medicinal mushroom for over 2000 years and its powerful effects have been documented in ancient scriptures (Wasser 2005). In the Supplement to the classic of Materia Medica (502-536 AD) and the Ben Cao Gang Mu of Li Shin-Zhen, which is considered the first pharmacopoeia in China (1590 AD, Ming dynasty), the fungus was attributed toning properties, the increase of vital energy, strengthening of cardiac function, memory increase and antiaging effects.
Mycotherapy uses the hat and the stem of the fungus. It is used primarily as an immunomodulator.

What does Ganoderma contain?
The active constituents include polysaccharides and triterpenes including the ganoderic acids. Some polysaccharides present in Reishi, beta-glucans, have shown antitumor and immunostimulant activity and can also induce the maturation of normal monocytes and leukemic blasts (immature cells) in dendritic cells. The identified triterpenes have adaptogenic, anti-hypertensive, anti-allergic effects and can also inhibit tumor invasion by reducing the expression of metalloproteinases and decreasing tumor metastases by limiting attachment to endothelial cells.
In addition to these, mushrooms contain a wide variety of bioactive molecules, such as steroids, phenols, nucleotides and their derivatives, glycoproteins. Mushroom proteins contain all the essential amino acids and are particularly rich in lysine and leucine.
The low total fat content and the high percentage of polyunsaturated fatty acids compared to the total fatty acids of fungi are considered significant contributions to the health value of fungi (Chang and Buswell 1996, Borchers et al., 1999; Sanodiya et al., 2009).
Potassium, calcium, phosphorus, magnesium, selenium, iron, zinc and copper represent the majority of the mineral content (Borchers et al., 1999) of this fungus. Ganoderma also contains organic Germanium (according to research by Dr. Kazuhiko Asai, it contains 800-2000 parts per million of germanium, ie 4-6 times more than the amount contained in Panax Ginseng): although germanium is not an essential element, low doses, it has been credited with immunopotenzanti, anticancer, antioxidant and antimutagenic activity (Kolesnikova, Tuzova and Kozlov 1997). Organic germanium is an oligoelement that is essential to improve oxygen at the cellular level and for this reason is considered a powerful antioxidant. Its presence is recommended in all cases of chronic degenerative diseases, both cardiovascular and metabolism in general (diabetes, dyslipidemia, cancer).

What are your actions?
Reishi extracts are able to:
- increase the immune defenses, through the stimulation of macrophages, the action on the levels of TNF-a (Tumor necrosis factor) and interleukins;
- increase the antioxidant capacity of the plasma and improve the immune responses in some cancer patients;
- improve the symptoms of the lower urinary tract in men by inhibiting 5-alpha-reductase, an important enzyme that converts testosterone into dihydrotestosterone, which is upregulated in benign prostatic hyperplasia;
- have chemopreventive effects, alleviate chemotherapy-induced nausea, improve the efficacy of radiotherapy, and increase the sensitivity of ovarian cancer cells to cisplatin. It was also effective in preventing cisplatin-induced nephrotoxicity;
- exercise mild anti-diabetic effects and may improve dyslipidemia;
- Demonstrate antihypertensive activity as an ACE inhibitor (Angiotensin Converting Enzyme) and a good antioxidant capacity. Cardio-protective effects were highlighted in a 2011 study of 26 people with medium hypertension;
- protect the liver from the toxicity induced by various toxic substances. Moreover, it has been found the protective power in vivo against hepatic necrosis induced by harmful substances. Positive effects on patients with chronic hepatitis B were evidenced by the polysaccharide fraction of the fungus. In some cases a remission of hepatocellular carcinoma has been described;
- act as an anti-allergic: studies on the anti-allergic action have shown the inhibition of the production of histamine and, more in general, a modulation of the immune system, with rearrangement of a correct balance of Th1 / Th2 lymphocytes. In vivo studies have shown efficacy in cases of allergic rhinitis models. The ganoderic acids (mainly the ganoderic acid C) have shown anti-inflammatory activity both systemically and topically in vivo. Acids A, B, G and H showed higher activity than acetylsalicylic acid. One study showed that 50 mg of this fungus has an anti-inflammatory effect of 5 mg of hydrocortisone.
Further research is underway to determine its safety and efficacy, as an adjuvant in the treatment of cancer or even as an anticancer.

Drug interactions?
Regarding herbal-drug interactions, studies have documented interactions with: anticoagulants (Reishi may have inhibitory effect on platelet aggregation, Immunosuppressants (Reishi can improve immune responses), chemotherapeutic drugs (it should be borne in mind that Reishi can greatly increase the antioxidant capacity of the plasma).

Conclusions
In conclusion, Ganoderma lucidum is a well-known Asian fungus with a wide range of applications. With its growing popularity, numerous studies are underway on the composition, cultivation and reputational effects of Ganoderma, and there are data that support its positive health benefits, including anticancer effects; blood glucose regulation; antioxidant, antibacterial and antiviral effects; and protection against the liver and gastric lesions.
 
Dr. Laura Comollo

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Fonti

Huang K. The Pharmacology of Chinese Herbs. 2nd ed. New York: CRC Press; 1999.

Chen HS, Tsai YF, Lin S, et al. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem. Nov 1 2004;12(21):5595-5601.

Gao Y, Zhou S, Wen J, et al. Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat. Life Sci. Dec 27 2002;72(6):731-745.

Hsu MJ, Lee SS, Lin WW. Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway. J Leukoc Biol. Jul 2002;72(1):207- 216.

Wang SY, Hsu ML, Hsu HC, et al. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer. Mar 17 1997;70(6):699-705.

Wachtel-Galor S, Szeto YT, Tomlinson B, et al. Ganoderma lucidum (‘Lingzhi’); acute and short-term biomarker response to supplementation. Int J Food Sci Nutr. Feb 2004;55(1):75-83.

Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr. Feb 2004;91(2):263-269.

Gao Y, Zhou S, Jiang W, et al. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest. Aug 2003;32(3):201- 215.

Noguchi M, Kakuma T, Tomiyasu K, et al. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms. Asian J Androl. Sep 2008;10(5):777-785.

Noguchi M, Kakuma T, Tomiyasu K, et al. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study. Asian J Androl. Jul 2008;10(4):651-658.

Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ. 1990;10(4):240-243.

Wang CZ, Basila D, Aung HH, et al. Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model. Am J Chin Med. 2005;33(5):807-815.

Chen NH, Liu JW, Zhong JJ. Ganoderic Acid me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression. J Pharmacol Sci. Oct 2008;108(2):212-216.

Li YB, Wang R, Wu HL, et al. Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells. Oncol Rep. Sep 2008;20(3):549-556.

Mao T, van De Water J, Keen CL, et al. Two mushrooms, Grifola frondosa and Ganoderma lucidum, can stimulate cytokine gene expression and proliferation in human T lymphocytes. Int J Immunother 1999;15(1):13-22.

Chan WK, Cheung CC, Law HK, et al. Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. J Hematol Oncol. 2008;1(1):9.

Noguchi M, Kakuma T, Tomiyasu K, et al. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study. Asian J Androl. 2008 Jul;10(4):651-8.

Weng CJ, Yen GC. The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis. Clin Exp Metastasis. 2010 May;27(5):361-9.

Kim KC, Jun HJ, Kim JS, Kim IG. Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells. Int J Mol Med. 2008 Apr;21(4):489-98.

Gordan JD, Chay WY, Kelley RK, et al. And what other medications are you taking”. J Clin Oncol. 2011 Apr 10;29(11):e288-91.

Wanachiwanawin D, Piankijagum A, Chaiprasert A, et al. Ganoderma lucidum: a cause of pseudoparasitosis. Southeast Asian J Trop Med Public Health. 2006 Nov;37(6):1099-102.

Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Int J Oncol. 2011

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